胱天蛋白酶Caspase抑制剂Z-IETD-FMK
 |
货号 |
13305 |
存储条件 |
在零下15度以下保存, 避免光照 |
| 规格 |
1 mg |
价格 |
1200 |
| Ex (nm) |
|
Em (nm) |
|
| 分子量 |
654.69 |
溶剂 |
DMSO |
| 产品详细介绍 |
简要概述
产品基本信息
货号：13305
产品名称：胱天蛋白酶Caspase抑制剂Z-IETD-FMK
规格：1mg
储存条件：-15℃避光防潮
保质期：12个月
产品物理化学光谱特性
分子量：654.69
溶剂：DMSO
产品介绍
Z-IETD-FMK是一种细胞通透性不可逆caspase-8抑制剂。它广泛应用于细胞凋亡的研究。Caspase-8是半胱氨酸蛋白酶的一个成员，参与细胞凋亡和细胞因子的加工。与所有caspase一样，caspase-8是作为一种非活性的单肽链酶原原原蛋白酶合成的，通过蛋白水解酶裂解激活，既可以在被招募到多聚体复合物后自动激活，也可以被其他caspase反式裂解。因此，配体结合诱导的死亡受体三聚导致受体特异性结合蛋白Fas相关死亡结构域（FADD）的募集，进而成为caspase-8。已知激活的caspase-8通过直接切割和激活下游caspase或通过切割BH3-Bcl2相互作用蛋白来传播凋亡信号，从而导致线粒体释放细胞色素c，触发dATP和Apaf-1复合物中caspase-9的激活。激活的caspase-9然后进一步激活“下游caspase”，包括caspase-8。敲除数据表明caspase-8是由死亡受体Fas、肿瘤坏死因子受体1和死亡受体3诱导的杀伤所必需的。此外，caspase-8-/-小鼠由于心肌发育不全而在子宫内死亡，造血细胞减少，表明FADD/caspase-8通路对特定细胞类型的生长发育是绝对必要的。金畔生物是AAT Bioquest的中国代理商，为您提供最优质的胱天蛋白酶Caspase抑制剂Z-IETD-FMK。
参考文献
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说明书
胱天蛋白酶Caspase抑制剂Z-IETD-FMK.pdf
