Harlan肥胖模型高酯饲料 Diet induced obesity
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
Harlan肥胖高酯模型
Diet induced obesity
 
Purified high fat diets used to induce obesity and obesity-related complications such as diabetes and metabolic syndrome typically have 40-60% of energy derived from fat. The diet tables below summarize relevant diet features for several Teklad custom research diets commonly used in rodent models.
Teklad also creates high-fat diets for other species, including pigs, primates, and dogs. Contact us to discuss the use of these diets or one that better meets your needs.

*Control diets can be designed in several ways, depending on what features the researcher wants to modify relative to the high-fat diet. These are just a few examples.

饮食诱导肥胖

用于诱导肥胖和肥胖相关并发症(如糖尿病和代谢综合征)的纯化高脂饮食通常有40-60%的能量来源于脂肪。下面的饮食表总结了一些特克拉德定制研究饮食的相关饮食特征，这些研究饮食通常用于啮齿类动物模型。
泰克乐还为其他物种，包括猪、灵长类动物和狗创造高脂肪饮食。联系我们讨论使用这些饮食或更好地满足您的需要。

*控制饮食可以通过几种方式来设计，这取决于研究人员相对于高脂肪饮食想要改变什么特征。这些只是几个例子。

Diets for diet-induced obesity (DIO)
Diets with 55-60% of calories from fat like TD.06414 and TD.93075 are commonly used for inducing obesity in rodents. While considered extreme compared to typical human fat consumption, these diets are effective in initiating rapid weight gain in most rodents. With higher fat content there is less room for carbohydrate, thus the carbohydrate (particularly sucrose) amount is relatively low compared to other obesity inducing diets. If you are interested in high fat and high carbohydrate, look at diets with 40-45% of calories from fat (often referred to as western diets).
As the fat level increases, pellet quality (durability) is often compromised. Some higher fat formulas are available only in non-pelleted form or require specific carbohydrate, maltodextrin, for pelleting. Depending on the fat and carbohydrate sources used, the non-pelleted form could be dense and crumbly, dough-like, or paste-like. Though a little more challenging to work with, non-pelleted diet is still used by many researchers for diet-induced obesity models as these researchers suspect the softer form may enhance obesity development.
Diets with 40-45% of calories from fat, like TD.95217, TD.88137, TD.06415, and TD.08811, represent another popular diet pattern for diet-induced obesity work. These diets have double or triple the amount of sucrose found in higher fat diets. High levels of simple carbohydrate like sucrose and fructose may help to promote hypertriglyceridemia, insulin resistance, and fatty liver. Diets with a pattern of high sucrose and high saturated or trans fat are often referred to as “Western Diets” in obesity and cardiovascular fields. Some “Western Diets” have further modifications to the fatty acid profile or even specific vitamin and minerals adjustments to be even more closely matched to a Western Diet pattern. For specific fatty acid modifications, see examples on our fat/lipid adjusted diets page.
Diets for diet-induced diabetes
Many of the same diets used for inducing obesity in rodents can be used to enhance diabetes related phenotypes like insulin resistance and glucose intolerance. However, fasting hyperglycemia characteristic of diabetes (glucose > 200 mg/dL) is uncommon with a diet only approach. Pre-feeding a high fat diet to induce a certain level of obesity and insulin resistance and then giving low-dose streptozotocin (STZ) may be an effective approach if overt hyperglycemia is desired.
Ingredient matched, low-fat DIO control diets
There are many options with different levels and types of fat in addition to different types of carbohydrate ranging from sucrose (highly refined, simple digestion) to corn starch (refined, but more complex) to resistant starch (refined, but not fully digestible). A very basic purified control diet would be AIN-93M (TD.94048) or AIN-93G (TD.94045). AIN-93 diets have a moderate amount of sucrose at ~10%, and fat is from soybean oil with a healthy fatty acid profile. Additional examples of controls for specific DIO diets can be found in the above tables.
Many researchers choose to compare their high fat fed animals to animals fed a natural ingredient, grain-based diet (also referred to as standard diets or chow). These diets differ in the source and level of nutrients as well as in the presence of non-nutritive factors (such as phytates or phytoestrogens). Depending on what your main comparisons are, it may be suitable to have a grain-based diet as your control/reference group. However, making such comparisons limits inferences to dietary patterns versus a specific dietary component.

Harlan TD.96208氯化钠调节饲料 NaCl dite
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
NaCl adjusted (natural ingredient) | Harlan
The sodium content of natural ingredients such as corn, wheat, and soybean meal is low. Thus, these ingredients can be used to create a base diet that is sodium deficient. To this base diet, various amounts of sodium chloride salt (NaCl) can be added, and other ingredients adjusted slightly to maintain a relatively constant nutrient profile (with the exception of sodium and chloride). Below are examples from a popular series of adjusted NaCl diets. Contact us for more information.

* When added to natural ingredient diets, these water soluble food dyes offer a slight color tint. More intense color can be achieved at higher inclusion rates.
Ask a nutritionist about additional salt concentrations or color options.
These diets are grain-based, with no animal derived ingredients, and have a background sodium content of approx. 0.01-0.02% and a background chloride content of approx. 0.06-0.07%. The selected nutrient content of the diets are as follows: approximately 19% protein, 5% fat, 3% crude fiber, 0.86% Ca, 0.64% P, 0.72% K, and 0.15% Mg.
NaCl adjusted diets are often fed to dahl salt-sensitive/resistant (rapp) inbred rats. These rats are maintained on Teklad traditional diet 7034 (0.12% NaCl) within maximum security production facilities.

盐调节(天然成分)

玉米、小麦、豆粕等天然成分的钠含量较低。因此，这些成分可以用来制造一种缺乏钠的基础饮食。在这一基础日粮中，可以添加各种量的氯化钠盐(NaCl)，其他成分也可以稍加调整，以保持相对稳定的营养状况(除钠和氯化物外)。下面是一系列受欢迎的调整NaCl饮食的例子。欲了解更多信息，请与我们联系。

*将这些水溶性食物染料加入天然成分的饮食中，可提供轻微的色泽。在较高的包合率下可以获得更强烈的颜色。
向营养师询问额外的盐浓度或颜色选择。
这些饮食是以谷物为基础的，没有动物来源的成分，并且背景钠含量约为。0.01-0.02%，背景氯含量约为0.01-0.02%.0.06-0.07%。日粮的营养成分为：蛋白质约19%，脂肪5%，粗纤维3%，钙0.86%，磷0.64%，钾0.72%，镁0.15%。
食盐调节后的饲料通常喂给Dahl盐敏感/耐盐(Rapp)近交系大鼠.这些老鼠传统饮食7034(0.12%NaCl)在最大安全生产设施内。
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Harlan TD.81062 说明书 Iron deficient mineral mix based on AIN-76A
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
Formula
Calcium Phosphate, dibasic   500.0
Sodium Chloride   74.0
Potassium Citrate, monohydrate   220.0
Potassium Sulfate   52.0
Magnesium Oxide   24.0
Manganous Carbonate   3.5
Zinc Carbonate   1.6
Cupric Carbonate   0.3
Potassium Iodate    0.01
Sodium Selenite, pentahydrate   0.01
Chromium Potassium Sulfate, dodecahydrate    0.55
Sucrose, fine ground    124.03
Key Features
+ Mineral Mix
+ Modified From AIN-76
+ Iron Deficient
+ Rodent
Key Planning Information
+ Products are made fresh to order
+ Lead time 2 weeks
+Store in cool, dry conditions
+ Use within 12 months (applicable to most mixes)
+ Box labeled with product name,
manufacturing date, and lot number
Product Specific Information
+ Powder
+ Minimum order 500 grams
Footnote
This modification of the AIN-76 mineral mix (170915) uses a reagent
grade/pretested CaHPO4 to help reduce the inherent background iron
contributed from this compound. The mineral mix itself is tested for iron
content prior to use.
Options (fees will apply)
+ Rush order (pending availability)
+ Vacuum packaging (1 and 2 Kg)
CA.170481 AIN-76A Purified Diet AIN-76A 纯化饲料 50kg
TD.94045　AIN-93G Purified Diet AIN-93G 纯化饲料 50kg
TD.94048 AIN-93M Purified Diet AIN-93M 纯化饲料 50kg
TD.94096 version of AIN-76A suitable for irradiation （vitamin levels are increased） 适合辐照的AIN-76A 饲料 维生素含量增加 50kg
TD.97184　version of AIN-93G suitable for irradiation （vitamin levels are increased） 适合辐照的AIN-93G 饲料 维生素含量增加 50kg
TD.00102 version of AIN-93M suitable for irradiation （vitamin levels are increased） 适合辐照的AIN-93M 饲料 维生素含量增加 50kg
TD.95092 modification of AIN-93G where soybean oil is replaced with corn oil. AIN-93G饲料 豆油改为玉米油 50kg
TD.06414 Adjusted Calories Diet （60/Fat） 卡路里调控饲料 60%脂肪 50kg
TD.06415 Adjusted Calories Diet （45/Fat） 卡路里调控饲料 45%脂肪 50kg
TD.03584 35% Lard Diet （Adj., No C） 35%猪油饲料 50kg
TD.93075 Adjusted Calories Diet （55/fat） 卡路里调控饲料 55%脂肪 50kg
TD.95217 Adjusted Fat Diet 脂肪控饲料　50kg
TD.96132 Adjusted Fat Diet 脂肪控饲料 50kg
TD.88137 Adjusted Kcal Diet （42% from fat 大卡调控饲料 42%脂肪 50kg
TD.08811 45% Kcal Fat Diet （21% MF, 2% SBO） 45%大卡脂肪饲料 42%脂肪 50kg
TD.06416 Adjusted Calories Diet （10/Fat） （a possible control for TD.06415 &
TD.06414 listed above） 卡路里调控饲料 10%脂肪 50kg
TD.08810 Low Glycemic Control Diet 低血糖饲料 50kg
TD.96355 Ketogenic Diet 生酮饲料 50kg
TD.84224 Essential Fatty Acid Deficient Diet 必须氨基酸缺损饲料 50kg
TD.88137 Adjusted Calories Diet （42% from fat） 卡路里调控饲料 42%脂肪 50kg
TD.88051 Cocoa Butter and Purina Chow Diet 椰子油和Purina Chow饲料 50kg
TD.90221 Cocoa Butter Diet with 75% Purina Mouse （5015） 　 50kg
TD.94059 5015, Cocoa Butter, Chol., etc. （excludes cholate） 　 50kg
TD.02028　Atherogenic Rodent Diet （1.25% Chol. & 0.5% Cholic Acid） 50kg
TD.01383 2018 + 2% Cholesterol 　 50kg
TD.86143 Vitamin A Deficient Diet 50kg
TD.89123 Vitamin D Deficient Diet 50kg
TD.88163 Vitamin E Deficient Diet 50kg
TD.95247 Folic Acid Deficient Diet 50kg
TD.80396 Iron Deficient Diet 　 50kg
TD.85419 Zinc Deficient Diet 　 50kg
TD.88239 Potassium Deficient Diet 50kg
TD.95027 Low Calcium Diet （0.4% P） 50kg
TD.96348 Diet （20% Lactose, 2% Ca, 1.25% P） 50kg
TD.92163 Selenium Deficient Diet 　 50kg
TD.95125 Iodine Deficient （0.15% PTU） 50kg
TD.93328 Protein Free Diet 　 50kg
TD.90016 6% Protein Diet 　 50kg
TD.91352 20% Protein Diet 　 50kg
TD.90018 40% Protein Diet　　 50kg
TD.89247 60% Fructose Diet 　 50kg
TD.86489 Diet with Adjusted Sucrose/Cornstarch 　 50kg
TD.96348 Diet （20% Lactose, 2% Ca, 1.25% P） 　 50kg
TD.98090 70% Carbohydrate Diet 　 50kg
TD.96355 Ketogenic Diet （almost no carbohydrate）50kg
TD.99366 Amino Acid Diet 　 50kg
TD.90262 Methionine & Choline Deficient Diet 50kg
TD.00434 Folic Acid Deficient Diet 　 50kg
TD.99386 No Lysine AA Diet 　 50kg
TD.90228 Sodium Deficient Diet 　 50kg
TD.96208 0.49% NaCl Diet 　 50kg
TD.90229 1% NaCl Diet 　 50kg
TD.92034 4% NaCl Diet 　 50kg
TD.92012 8% NaCl Diet 　 50kg
TD.01306 Rodent Diet （2018 + 625 doxycycline） 　 50kg
TD.98186 Rodent Diet （7012 + 200 doxycycline） 　 50kg
TD.92033 Swine Diet （15% Lard, 1.2% Cholesterol） 50kg
TD.92052 Swine Diet （15% Lard, 1.5% Cholesterol） 50kg
TD.93296 Swine Diet （15% Lard, 2% Cholesterol） 　 50kg
CA.40060 Teklad Vitamin Mix 　 50kg
CA.40077 AIN-76A Vitamin Mix 　 50kg
TD.94047 AIN-93 Vitamin Mix 　 50kg
CA.170915 AIN-76 Mineral Mix 　 50kg
TD.94046 AIN-93G Mineral Mix 　 50kg
TD.94049 AIN-93M Mineral Mix　　 50kg

Harlan定制研究饲料 Diet ingredients
Harlan Teklad动物饲料
Harlan代理
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。
You may want to prepare your own diet at your research site or facility, and if that is the case, you depend on the ingredients being of the highest quality. Envigo can provide you with many of the same ingredients used to produce our advanced Teklad custom research diets so you can develop your own formula. And as always, our nutritional experts are here to help you make the best decisions for your ingredients and ultimate formulation.
Our ingredients
We offer several ingredients for individual sale so that you can develop your own blends.
“VFT” casein

• “Vitamin-free” test casein (alcohol-extracted) is best suited for purified test diet formulas where fat or vitamin content needs to be precisely controlled
• The reduced levels of many vitamins in VFT casein make it the preferred protein source for many vitamin studies. Thus, the nickname “Vitamin-free” was given to the extracted casein many years ago

Vitamin mixes

• The common vitamin mixes shown below use sucrose or corn starch as a carrier
• Customized vitamin mixes may use cellulose if a non-nutritive carrier is necessary
• Vitamin mixes are formulated with a diet inclusion rate in mind. Using more or less than recommended could impair the health of your laboratory animal
• For those preparing their own diets, vitamin premixes are an efficient way to add vitamins to a diet
• Vitamin mixes should be stored at 4 degrees celsius or lower upon receipt. Storage at –20 degrees celsius is recommended if the mix will be used beyond 1 month
• Minimum order is 500 g for both stock and custom vitamin mixes
• Our available vitamin mixes are commonly used in diets, and are available from stock
• Vitamin mixes are shipped within a few days of order

Our Formula examples

• CA.40060     Teklad vitamin mix
• CA.40077     AIN-76A vitamin mix
• TD.94047     AIN-93 vitamin mix

Mineral mixes

• The common mineral mixes shown below as examples use sucrose as a carrier
• Customized mineral mixes could use cellulose or no carrier if a non-nutritive carrier is necessary
• Our mineral mixes are formulated with a diet inclusion rate in mind. Using more or less than recommended could impair the health of the animal
• For those preparing their own diets, mineral premixes are an efficient way to add minerals to a diet
• Mineral mixes should be stored in a dry cool environment and used within a year of receipt. The minimum order is 500 g for both stock and custom mineral mixes
• These mineral mixes are commonly used in diets, and are available from stock
• Our mineral mixes are shipped within a few days of order

Formula examples:

• CA.170915    AIN-76 mineral mix
• TD.94046      AIN-93G mineral mix
• TD.94049      AIN-93M mineral mix

Other mixes (may or may not be available from stock):

• TD.83171     Vitamin mix without A, D, E, choline
• TD.81062     Iron deficient mineral mix based on AIN-76A
• TD.79055     Calcium and phosphorus deficient mineral mixed based on AIN-76
• TD.98057     Calcium and phosphorus deficient mineral mixed based on AIN-93
• CA.170760   Rogers-Harper mineral mix

你可能想要在你的研究地点或设施准备你自己的饮食，如果是这样的话，你取决于成分是最高的质量。Envigo可以为您提供许多相同的成分，用于生产我们先进的特克拉德定制研究饮食，以便您可以开发自己的配方。和往常一样，我们的营养专家在这里帮助您为您的配料和最终配方做出最佳决定。
我们的配料
我们提供几个配料供个人销售，以便您可以开发自己的混合。
“VFT”酪蛋白

• “无维生素”测试酪蛋白(酒精提取)最适合于那些需要精确控制脂肪或维生素含量的纯正试验饮食配方。
• VFT酪蛋白中许多维生素含量的降低使得它成为许多维生素研究的首选蛋白质来源。因此，“无维生素”的绰号是在许多年前给提取出来的酪蛋白起的。

维生素混合物

• 以下常见的维生素混合物使用蔗糖或玉米淀粉作为载体。
• 定制的维生素混合物可能使用纤维素，如果非营养载体是必要的。
• 维生素混合物的制定考虑到了饮食中的包容率。多用或少用会损害你的实验动物的健康。
• 对于那些自己准备饮食的人来说，维生素预混剂是向饮食中添加维生素的一种有效方法。
• 维生素混合物应储存在4摄氏度或更低的接收。如果使用时间超过1个月，建议使用摄氏-20度。
• 库存和定制维生素混合物的最低订购量为500克。
• 我们可用的维生素混合物通常用于饮食，并可从库存中获得。
• 维生素混合物在订购后几天内发货。

我们的公式示例

• CA.40060特克拉德维生素混合物
• CA.40077AIN-76A维生素混合物
• TD.94047AIN-93维生素混合物

矿物混合物

• 下面所示的常见矿物混合物是以蔗糖为载体的。
• 如果需要非营养的载体，定制的矿物混合物可以使用纤维素，也可以不使用载体。
• 我们的矿物质混合物是根据饮食包容率来制定的。多用或少用会损害动物的健康。
• 对于那些自己准备饮食的人来说，矿物预混料是向饮食中添加矿物质的有效方法。
• 矿物混合物应存放在干燥、凉爽的环境中，并在收到后一年内使用。库存和自定义矿物混合物的最低订购量为500克。
• 这些矿物混合物通常用于饮食，并可从库存中获得。
• 我们的矿物混合物在订货后几天内装运。

公式示例：

• CA.170915AIN-76矿物混合物
• TD.94046AIN-93g矿物混合物
• TD.94049AIN-9300万矿物混合物

其他混合材料(可能从库存中获得，也可能无法从库存中获得)：

• TD.83171不含A，D，E，胆碱的维生素混合物
• TD.81062基于AIN-76A的缺铁矿物配料
• TD.79055AIN-76混合钙磷缺乏矿物
• TD.98057AIN-93混合钙磷缺乏矿物
• CA.170760罗杰斯-哈珀矿物混合物