荧光底物Mca-PLAQAV-Dpa-RSSSR-NH2

	货号	13560	存储条件	在零下15度以下保存, 避免光照
	规格	1 mg	价格	1836
	Ex (nm)	322	Em (nm)	381
	分子量	1638.96	溶剂	DMSO
	产品详细介绍

简要概述

产品基本信息

货号：13560

产品名称：荧光底物Mca-PLAQAV-Dpa-RSSSR-NH2

规格：1mg

储存条件：-15℃避光防潮

保质期：24个月

产品物理化学光谱特性

分子量：1638.96

溶剂：DMSO

激发波长(nm)：322

发射波长(nm)：381

校正系数（280nm）:0.3

产品介绍

Mca-PLAQAV-Dpa-RSSSR-NH2是用于检测肿瘤坏死因子-α转换酶（TACE或ADAM17）和相关酶（如ADAM8，ADAM9和ADAM10）的荧光肽底物。其N端包含高荧光的7-甲氧基香豆素（MCA）荧光团，可通过荧光共振能量转移（Dark FRET）通过Dpa上的非荧光2,4-二硝基苯基有效地淬灭。它可用于测量能够裂解荧光基团和淬灭基团之间酰胺键的肽酶活性，从而增加荧光强度。该肽序列衍生自促肿瘤坏死因子-α（TNF-α）。 TACE / ADAM17和ADAM10的切割位点是A（Ala）和V（Val）残基之间的肽键。金畔生物是AAT Bioquest的中国代理商，为您提供最优质的荧光底物Mca-PLAQAV-Dpa-RSSSR-NH2。 

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参考文献

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Photic injury promotes cleavage of p75NTR by TACE and nuclear trafficking of the p75 intracellular domain.
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Relationships between early inflammatory response to bleomycin and sensitivity to lung fibrosis: a role for dipeptidyl-peptidase I and tissue inhibitor of metalloproteinase-3?
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Characterization of Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2, a fluorogenic substrate with increased specificity constants for collagenases and tumor necrosis factor converting enzyme.
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Journal: Analytical biochemistry (2004): 166-73