胱天蛋白酶Caspase抑制剂Z-IETD-FMK

	货号	13305	存储条件	在零下15度以下保存, 避免光照
	规格	1 mg	价格	1200
	Ex (nm)		Em (nm)
	分子量	654.69	溶剂	DMSO
	产品详细介绍

简要概述

产品基本信息

货号：13305

产品名称：胱天蛋白酶Caspase抑制剂Z-IETD-FMK

规格：1mg

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

分子量：654.69

溶剂：DMSO

产品介绍

Z-IETD-FMK是一种细胞通透性不可逆caspase-8抑制剂。它广泛应用于细胞凋亡的研究。Caspase-8是半胱氨酸蛋白酶的一个成员，参与细胞凋亡和细胞因子的加工。与所有caspase一样，caspase-8是作为一种非活性的单肽链酶原原原蛋白酶合成的，通过蛋白水解酶裂解激活，既可以在被招募到多聚体复合物后自动激活，也可以被其他caspase反式裂解。因此，配体结合诱导的死亡受体三聚导致受体特异性结合蛋白Fas相关死亡结构域（FADD）的募集，进而成为caspase-8。已知激活的caspase-8通过直接切割和激活下游caspase或通过切割BH3-Bcl2相互作用蛋白来传播凋亡信号，从而导致线粒体释放细胞色素c，触发dATP和Apaf-1复合物中caspase-9的激活。激活的caspase-9然后进一步激活“下游caspase”，包括caspase-8。敲除数据表明caspase-8是由死亡受体Fas、肿瘤坏死因子受体1和死亡受体3诱导的杀伤所必需的。此外，caspase-8-/-小鼠由于心肌发育不全而在子宫内死亡，造血细胞减少，表明FADD/caspase-8通路对特定细胞类型的生长发育是绝对必要的。金畔生物是AAT Bioquest的中国代理商，为您提供最优质的胱天蛋白酶Caspase抑制剂Z-IETD-FMK。 

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