荧光素醛[5-FAM醛]

	货号	9000	存储条件	在零下15度以下保存, 避免光照
	规格	5 mg	价格	3732
	Ex (nm)	493	Em (nm)	517
	分子量	550.52	溶剂	DMSO
	产品详细介绍

简要概述

产品基本信息

货号：9000

产品名称：荧光素醛[5-FAM醛]

规格：5 mg

储存条件：-15℃避光防潮

保质期：24个月

产品物理化学光谱特性

分子量：445.43

溶剂：DMSO

激发波长(nm)：493

发射波长(nm)：517

消光系数（cm-1 M-1）:83000

校正因子（260nm）:0.32

校正因子 (280 nm)：0.178

产品介绍

荧光素醛是可以与胺，肼或羟胺反应的反应性荧光染料。荧光素是使用最广泛的绿色荧光染料。醛基可与pH 5-9的胺，酰肼或羟胺基反应。与胺反应性琥珀酰亚胺基酯基（NHS）不同，醛可以在酸性pH下与N端胺基反应，这是某些生物缀合反应有时需要的条件。醛与胺基反应形成席夫碱（Schiff base）。用氢化物进一步还原将形成稳定的C-N键。醛与其他基团之间的反应可实现荧光素染料的位点特异性缀合和标记，使其靶向分子上的所需位置。共轭荧光素染料可以很容易地通过普通的荧光仪器在FITC通道下检测到。

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参考文献

2-Formyl-dATP as Substrate for Polymerase Synthesis of Reactive DNA Bearing an Aldehyde Group in the Minor Groove.
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Aldehyde dehydrogenase-2 activation decreases acetaminophen hepatotoxicity by prevention of mitochondrial depolarization.
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Bisretinoid phospholipid and vitamin A aldehyde: Shining a light.
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Journal: Journal of lipid research (2020)

Characterization of ascites-derived aldehyde dehydrogenase-positive ovarian cancer stem cells isolated from Leghorn chickens.
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Citral Inhibition of Human Salivary Aldehyde Dehydrogenase.
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Journal: Cell biochemistry and biophysics (2020): 31-42

Didactic approach recounting advances and limitations in novel glutathione and cysteine detection (reduced GSH probe) with mixed coumarin, aldehyde, and phenyl-selenium chemistry.
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Establishing sample-preparation protocols for X-ray phase-contrast CT of rodent spinal cords: Aldehyde fixations and osmium impregnation.
Authors: Barbone, Giacomo E and Bravin, Alberto and Mittone, Alberto and Kraiger, Markus J and Hrabě de Angelis, Martin and Bossi, Mario and Ballarini, Elisa and Rodriguez-Menendez, Virginia and Ceresa, Cecilia and Cavaletti, Guido and Coan, Paola
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Introduction of an Aldehyde Handle on Nanobodies by Affinity-Guided Labeling.
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Journal: Bioconjugate chemistry (2020): 1295-1300

Isocyanoacetate-Aldehyde Polymerization: A Facile Tool toward Functional Oxazoline-Containing Polymers.
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Journal: Macromolecular rapid communications (2020): e2000179

Preparation and optical parameter characterization of two aldehyde derivative thin films for photonic applications by drop casting method.
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Journal: Luminescence : the journal of biological and chemical luminescence (2020): 903-912